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Furthermore, in these regenerating fragments, the mitotic profile triggered by amputation during the early phase of regeneration was indistinguishable from controls.
The first 3 time points of Figure 2 A are part of the preparation phase of regeneration.
The preparation phase of regeneration in urodeles shares many similarities with wound healing in mammals [2], [9], [10].
It is possible that, in the preparation phase of regeneration, TGF-β1 could be expressed to promote detachment and migration of mesenchymal cells towards the blastema.
The spatio-temporal expression pattern of TGF-β1 in regenerating limbs shows that this gene is up-regulated during the preparation phase of regeneration.
Our interpretation is that these fragments may participate in signaling at early phase of regeneration (0 12 hours) while the full length Vimentin acts at later stages of remodeling (days).
Similar(41)
Regenerating axons exhibited a dynamic pattern with alternating phases of regeneration and pruning over a chronic period.
Working with version 4.1 of the database, released February 2017 (https://lris.scinfo.org.nz/layer/423-lcdb-v41-land-cover-database-version-41-mainland-new-zealand/), the carbon map was restricted to old-growth forest (i.e., LCDB class 69 = indigenous forest, comprised mostly of natural forests at various phases of regeneration following disturbance by wind, earthquakes, bark-beetle outbreaks etc).
Specifically, we used micro cDNA amplification methods and custom gene microarrays [15] [16] to interrogate nearly all identified transcription factor (TF) genes in the SE of the chick cochlea and utricle during the early phases of regeneration.
Four and seven days after PHx, there were no differences in liver weights, indicating that other phases of regeneration were unaffected.
The early wound-healing response initiates local environmental changes of the injury site that are pivotal to subsequent phases of regeneration.
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