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In addition, ALCAM is a marker of cancer stem cells and its expression at the tumor cell surface has been correlated with shortened survival in colon-rectal cancers [17]; [22] and with the vertical growth phase of progression in cutaneous melanoma [23].
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The parameters used in order to define late entry have therefore included a combination of clinical and immunological aspects, with the aim of identifying the phases of progression of HIV infection in which therapeutic interventions are no longer effective.
Changes in axial diffusivity, radial diffusivity, and FA, may indicate different types of white matter abnormality, which may reflect different phases of progression of TBI.
Among various phases of progressions, angiogenesis is one of the most important steps, as the aggressive growth of solid tumours is dependent on angiogenesis.
In fact, for a majority of T&F events, best performances show a secular progression hindered by the two WWs before reaching a phase of slower progression at the end of the XXth century (Fig. 2).
In the early phase of tumor progression, TGF-β/SMAD plays a tumor suppressing role (Massague et al., 2000).
Performing immunohistochemistry, Treg could hardly be detected on serial sections during the phase of disease progression (data not shown).
Treatment with a blocking ICAM-I antibody in the phase of disease progression led to a milder disease course.
While treatment with a blocking ICAM-I antibody in the phase of disease progression led to a milder disease course, administration during early clinical remission aggravates clinical symptoms.
Therefore, AT-EAE animals were treated with a high dose of purified monoclonal antibodies to ICAM-I, either in the phase of disease progression or in early clinical remission.
The administration of 1 mg anti-ICAM-I antibody during the phase of disease progression resulted in a significant suppression of EAE in comparison to sham-treated animals (Figure 3A).
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