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Therefore, clients who were on combination therapy were actually on 2 or more medications and were not in a transitional phase of discontinuation of one drug and an initiation of another drug.
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Eighteen (5.2%) participants of the 345 in the efficacy population were excluded from the time to median events analysis in the maintenance phase because of discontinuations before the first maintenance-phase visit or lack of evaluable maintenance-phase efficacy data [ 22].
However, in the absence of maintenance treatment data for pediatric bipolar disorder, the investigators believed that the discontinuation phase of the study provided clinical equipoise between the potential risks of side effects related to long-term lithium exposure, and the potential risks for relapse in patients randomized to placebo.
We did not find in the literature any study exploring the post-discontinuation phase of neuromuscular blocking agent apart the fact that blood oxygenation improved after interruption of cisatracurium infusion.
Furthermore, the rates of discontinuation during the 1-year core phase of the study were similar for patients randomized to DFO or deferasirox (Vichinsky et al, 2007).
Incomplete treatment refers to discontinuation at any phase of the previous treatment reported by patients.
Note that the primary care physician of each patient was contacted to explain that the patients should not receive adjunctive benzodiazepines during the maintenance phase and medication discontinuation follow-up phase of the study.
Rates of discontinuation of telaprevir for adverse events were similar to Phase 3 trials.
At the time of discontinuation, 20 patients had met the inclusion criteria for Phase II.
The final effect was that the sum of model-specific estimates of discontinuation from all states in the model, including each type of adverse event, matches the annual CATIE phase 1 discontinuation rates for any cause.
There was a high rate of discontinuation; however, discontinuations in the current study were consistent with the 33 42% discontinuation rate in other fibromyalgia phase 3 clinical trials.
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