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Symptoms remaining after recovery from the acute phase of brain inflammation vary considerably, depending on the type of encephalitis and on the age and general health of the patient.
Microglia activation is not only relevant to the acute phase of brain dysfunction after sepsis.
In children, cortical laminar necrosis is usually seen in the subacute or chronic phase of brain damage in hypoxic-ischemic encephalopathy.
It is therefore possible that perinatal PFOS exposure during a critical phase of brain development exerts a neurotoxic effect on the central nervous system via the molecules of the calcium signal pathway [193].
Several reports have proposed that subtle long-lasting neurobiological alterations might be triggered by exposure to opiate derivatives or drugs of abuse particularly when this occurs during a critical phase of brain maturation such as adolescence.
Disease onset during adolescence coincides with an important phase of brain development.
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Patient characteristics and neurologic data at baseline were analyzed as well as BG level and mean doses of insulin within the first five days which was considered as the acute phase of brain-injury and intra-cerebral hypertension.
If that happens during the key phases of brain development in the first 3 to 4 months of pregnancy, the overall size of the brain would be dramatically reduced, leading to microcephaly.
hCA VII has also been reported to be involved in the initial postnatal phases of brain development, as well as in the generation of neuronal excitation and febrile seizures; thus, its inhibition could represent a promising approach in designing new pharmacological agents useful for controlling such pathological conditions.
Moreover, a differential role of GPR17 may also depend on specific phases of brain response after the insult (sequentially, death of irreversibly damaged cells, clearance of dead cells, remodeling and repair).
Rakic (1988) described three broad phases of brain development in rhesus monkeys: generation of neurons, neuronal migration, and synaptogenesis.
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CEO of Professional Science Editing for Scientists @ prosciediting.com