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The inorganic phase of bone is comprised primarily of very small mineralites.
The diphosphonates bind to the calcium-rich tissue and the mineral phase of bone hydroxyapatite [27, 28].
After an initial phase of bone marrow oedema lasting just a few weeks, the fatty marrow conversion takes place.
Calcium phosphates are biocompatible materials with the composition closest in similarity to the mineral phase of bone.
The good biocompatibility of such coatings is caused by the fact that HAP is the mineral phase of bone (~60 %) and teeth (~85 %) [3, 7].
This is very relevant to engineering features in scaffolds to match the lag phase of bone repair (Chen et al. [2010d]).
The transient nature of the precursor phase of bone, if it exists at all, makes it very difficult to detect, especially in vivo (Grynpas and Omelon 2007).
We also evaluated the immunolabelling of fibronectin (FN) and collagen type III (Col III), two determinant proteins for the early phase of bone repair.
Calcium phosphate (CaP) has traditionally been used for the repair of bone defects because of its strong resemblance to the inorganic phase of bone matrix.
Hydroxyapatite, one form of calcium phosphate coating, is widely used as a biocompatible material for bone tissue replacement, since it has the ability to bond to osseous tissue due to compositional similarity to the mineral phase of bone.
Considering we were only able to obtain one monocortical screw fixation on the mobilized portion of the maxillae, maintaining immobility during the critical phase of bone healing was an obvious liability.
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