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"The first detection of the atmosphere of a planet means that for the first time we have entered into a new phase in the era of extrasolar planet discovery and characterization".
Tinder represents a new phase in the era of online dating.
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This discovery ushered in the era of antibiotic wonder drugs.
The portal-venous phase is generally considered adequate, especially in the era of multi-detector CT.
These results support the hypothesis that in the era of Phase-I trials studying MTAs, patients could derive prolonged disease stabilisation, and thus potential for clinical benefit even on lower dose levels; this in turn may influence the way current Phase-I cancer trials are planned, implemented, and analysed.
Conventional wisdom, that we should avoid prolonging the final phase of our lives, needs to be reassessed in the era of longevity.
Phase-I trials have been developed and designed in the era of conventional cytotoxic drug development (Eisenhauer et al, 2000).
In the era of molecularly targeted therapy, phase 1 trials based on biomarkers and cancer genomics have played a significant role in drug development and are critical to the translation of preclinical success to the practice of oncology [ 11– 11].
In the era of molecularly targeted therapy, phase 1 trials have been conducted not only to achieve this primary goal but also to identify specific target patient populations and produce preliminary biomarker evidence of targeted therapy [ 11].
While RCCTs in unselected patients are problematic in the era of targeted therapies, the Simon 2-stage phase II trial design may also no longer be appropriate in many situations.
The purpose of this study was to investigate whether, in the era of MTA, the chance of benefit in Phase-I trials depended on the dose received, that is, was there any detriment for patients enroled at early dose levels.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.
Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com