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These CpGs were then candidates for phase II validation, where a p-value ≤0.05 was considered significant.
We demonstrate the most significant covariates in the phase I dataset to be polymorphisms in two transporter genes, SCLO1B1 and ABCC2, and the phase II validation set revealed significant associations with polymorphisms in ABCG2.
For the Phase II validation cohort, 1 ml of plasma was assayed for each time point.
The phase II validation cohort confirmed the prognostic significance of plasma mGSTP1 DNA levels.
A two-phase approach was used for this study: Phase I: Item generation and refinement, and Phase II: Validation.
Phase II: Validation of the translated scales It was the pilot phase, semi structured interviews were conducted with the patients and parents.
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The Research Developmental Phase II: Model validation was employed in this study.
Phase II (Retrospective Validation).
Plasma samples were collected prospectively from a Phase I exploratory cohort of 75 men with castrate-resistant PC (CRPC) and a Phase II independent validation cohort (n=51).
Phase II included the validation of questionnaire from phase I by applying it on students pursuing professional education.
Cyclosporine A also showed promising results in a phase II study; however, validation by a multicentre, randomized phase III clinical trial is pending [ 207].
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