Sentence examples for phase ii proof from inspiring English sources

Phase II proof of concept (POC) (IIa) and dose-finding (IIb) studies represent major challenges in drug development.

Schneider et al. [ 2] have pointed out that, to date, no anti-amyloid phase III study has been preceded by a positive phase II proof of concept study.

Therefore, a systematic implementation of model based drug discovery has been advocated to increase the phase II proof of concept success rate.

The pilot trial will be a phase II proof of concept RCT to evaluate the effect of the MenSS IDI on increasing condom use in addition to usual clinic care for men in sexual health clinics.

In phase II proof of concept studies, it is desirable to select a homogeneous experimental group of patients in order to avoid the dilution of the potential efficacy endpoint by inconsistent effects across a heterogeneous pattern of response.

Larger Phase II proof-of-concept RCTs could have clarified safety risks thus modifying (e.g., drug dose, duration, specific safety signal monitoring) or avoiding pivotal Phase III RCTs.

Our review of Phase II proof-of-principle RCTs aligns with recent emphasis on Phase II RCTs [32] and complements other suggestions to improve chances of success in critical care RCTs [4].

Afatinib has also shown clinical activity similar to cetuximab in a Phase II proof-of-concept HNSCC trial.

Preliminary phase II proof-of-concept data suggest its efficacy in psoriasis [ 194]; additional phase II study results are expected.

We studied the proposed interventions in a randomised, double-blind, placebo-controlled, phase II proof-of-concept clinical trial.

A 30-month randomised, double-blind, placebo-controlled, parallel design, phase II proof-of-concept clinical study.