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Fig. 1 Pre-randomization phase assessments and interventions.
In the development phase assessments are made of the way the recovery phase was implemented and of lessons learned that should be included in future recovery plans.
Toothpaste or mouthwash were not allowed during the phase assessments.
Details of phase assessments have been described previously [23].
During phase assessments subjects remained in dim light (4,100°K lamps covered with red filters, <3.8 µW/cm2) and provided saliva samples every 30 minutes.
Circadian phase assessments were conducted before and after the ultradian days to determine the change in circadian phase, which was attributed to tau.
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These were all assessed immediately after study enrollment and thus prior to the phase assessment.
Following the 4 treatment days a final phase assessment was conducted to determine the time of the DLMO and assess the phase shift of the DLMO from the baseline to the final phase assessment.
Lack of reporting sufficient data and/or replicable laboratory protocols (first phase assessment) resulted in exclusion of 60% of relevant articles.
The 5-day session included a baseline phase assessment, followed by 3 days of an ultradian light/dark cycle [3], [18], and then a final phase assessment (Figure S1).
Each subject experienced a baseline dim light phase assessment in the laboratory to determine their endogenous melatonin profile.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com