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Concerns about isolation, compromised development, partial pharmacotherapy response, therapist scarcity, and inadequate cognitive-behavioral therapy (CBT) adherence led the authors to adapt a CBT protocol to a group format for adolescents with obsessive-compulsive disorder (OCD).
The tertiary outcome was to determine the predictors of pharmacotherapy response in ADWA.
To analyze the correlation between the pharmacotherapy response and the characteristics of the pre-treatment regional cerebral blood flow (rCBF) in patients with obsessive-compulsive disorder (OCD).
In the current dataset, however, we were unable to demonstrate any associations between baseline activity and pharmacotherapy response for the combined group.
Exploratory analyses of socio-demographic and clinical predictors of scores on the Hamilton Anxiety Rating Scale (HAM-A), the primary outcome measure, were also undertaken to determine the predictors of pharmacotherapy response in ADWA.
On the basis of previous studies, we proposed that abnormal activation involving forebrain and posterior brain regions might affect the interference processes that are associated with the pathophysiology of OCD, and that a difference in pre-treatment rCBF might predict the pharmacotherapy response to different treatments.
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Only two of 16 studies conducted subgroup analyses to reveal possible effects of pharmacotherapy on response patterns.
It embraces its indications and contraindications; whether it can (or should) be combined with other forms of treatment, including pharmacotherapy; typical responses to the treatment, and any adverse effects; common difficulties encountered, and how to address them; and when to abbreviate or extend the treatment, and when to abandon it.
Another multicenter study by Kocsis et al., in which the use of CBASP amongst other alternatives was assessed as an augmentative strategy to psychopharmacology, revealed that CBASP in addition to pharmacotherapy led to response rates of the same order as the comparator conditions (supportive therapy with pharmacotherapy or optimized pharmacotherapy) [ 16].
It suggests that pharmacotherapy elicited divergent responses in orbitofronto-striato-thalamic and premotor circuits, which warrants the design of longitudinal studies investigating the potential of these neuromarkers in stratified treatments of OCD.
Indications for allergen immunotherapy in a patient with allergic asthma include increased symptoms after exposure to the allergen demonstrated evidence of clinically relevant specific IgE antibodies and one of the following: poor response to pharmacotherapy or allergen avoidance, desire to avoid long-term pharmacotherapy, or coexisting allergic rhinitis [ 3].
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