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Our results also demonstrate that MeuKTX and BmKTX have the same channel spectrum and similar pharmacological potency.
Pharmacological evidence showing a clear correlation between receptor affinity and in vivo pharmacological potency for several benzodiazepines7 and a link between benzodiazepine receptors and GABA (γ-aminobutyric acid) receptors at the molecular level8,9, indicates that these receptors are relevant to the pharmacological and clinical effects of benzodiazepines.
These results suggest that aging influences the microenvironment for adult and immature neurons in the brain, which may affect the proliferation and migration of neural stem/progenitor cells, and YKS has pharmacological potency for these age-related events.
Based on the pharmacological potency and structural features of succinimides, this study was designed to synthesize new ketoesters derivatives of succinimides.
Thus, data concerning the extraction and polyphenolic composition from Hypericum triquetrifolium Turra, a plant with pharmacological potency [2, 3], are very scarce.
"They are adjusting synephrine to the same pharmacological potency so that it will have the same cardiovascular and neurological effects of ephedrine," says Arthur Grollman, professor of medicine and pharmacology at the State University of New York, Stony Brook.
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As a result, the clonal selection of a suitable host model and/or lower receptor expression levels within the same cell system becomes important especially when a functional assay is necessary to evaluate the pharmacological potencies of ligands at the receptor site.
The Pharmacological potencies of plants' secondary metabolites are well demonstrated.
Nevertheless the large amount of by-product generated in the process prompted studies on the extract's pharmacological potencies [ 7, 8].
Similar pharmacological potencies were reported in chondrocytes [ 19] and synoviocytes [ 20] exposed to an inflammatory stimulus, giving a rationale to the anti-inflammatory effect of PPARγ agonists in experimental arthritis [ 10, 21].
Though the formulations differ in pharmacological profile, potency, dosage, and approved indications, BoNT is recognized as a safe and effective treatment for spasticity resulting from stroke, multiple sclerosis and spinal cord injury, as well as for dystonia, tremor, and other movement disorders [12].
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