We predict an increasing application of Drosophila (and other genetic models) to the study of human sleep disorders, drug target discovery and the development of pharmacological screening platforms.
Furthermore, our human model offers an ideal platform for pharmacological screenings with the goal to restore physiological spastin levels in SPG4 patients.
Spliceosensor flies were grown on a 96-well plate, allowing the establishment of an in vivo platform for pharmacological screening for compounds that modify the DM1 phenotype.
Finally, our triple modified MCF10A cell line system for BBC may provide a useful platform for pharmacological studies to explore the potential therapeutic benefit of simultaneous targeting of these three genes in BBC.
Recently, studies investigating novel methylated TSG specific to the tumor types have made use of mRNA expression arrays to analyze more than 40,000 genetic regions on a single platform via pharmacological unmasking and discovery approaches (Yamashita et al. 2002; Tokumaru et al. 2004).
Engineered tissues are also finding applications as platforms for pharmacological and physiological studies in vitro.
A further interest is the use of multi-MPS platforms for pharmacological studies, which requires careful consideration of operational and biological parameters to attain desired distribution and exposure of exogenous and endogenous molecules in the various compartments.
While providing a platform to test pharmacological interventions, this model demonstrates that treating viral exacerbations with alternative anti-inflammatory drugs, such as PPAR-gamma agonists should be further explored since they showed greater efficacy than systemic corticosteroids.
This study demonstrates that drug repositioning can be rapidly guided by a knowledge platform PharmDB, a pharmacological network database comprising protein, drug, and disease data which we are providing as a web-based service.
With the current rapid growth of hybrid PET/MRI systems in diagnostic radiology, our molecular design of dual-modality agents possessing a "single pharmacological behavior" offers a versatile platform for the development of multimodality imaging agents with potential applications for noninvasive molecular profiling of various diseases.
