As we see it, there are at least three ways forward: (1) to develop new standard ecotoxicity tests better suited for pharmaceuticals, or (2) to adjust existing standard tests by supplementing them with additional endpoints relevant for different pharmacological modes-of-action, or (3) to increase the use of non-standard tests for risk assessment purposes.
Aripiprazole has a unique pharmacological mode of action that differs from current antipsychotics.
Because of their distinct pharmacological mode of action, it has been possible to achieve a significant reduction of treatment time.
This approach illustrates how mechanistic understanding of the pharmacological mode of action of effective agents can be translated into an effective chemoprevention strategy.
The exact CVI severity grade to be selected for the study depends on the drug and its pharmacological mode of action.
Nonetheless, agomelatine's demonstrable acute efficacy is intriguing given its unique pharmacological mode of action and good tolerability, and our findings certainly support further research into compounds possessing melatonergic activity.
Given that the p53 pathway is inactivated in most human cancers, these findings indicate that IGF2 targeting may become a pharmacological mode of tumour-type-specific intervention that could theoretically be applicable to a wide range of cancers.
Once a BP diagnosis is made, concerns remain regarding the primary, pharmacological mode of treatment: data supporting the efficacy of the often complex regimens are weak and side effects can be significant.
61 Diarrhoea, which occurred in less than 20% of linaclotide-treated patients in the Phase 3 studies, can be considered to be a consequence of the therapeutic effect of linaclotide driven by the pharmacological mode of action to relieve constipation (increased fluid secretion and accelerated colonic transit).
The read-across hypothesis can be viewed simply as what we see in one species is likely to be reflected in others, that conserve the same target, at the level of a pharmacological response (mode of action); that is, we see the same end result.
