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Recently, Paolini et al. 6 mapped the human pharmacological interaction network using the definition that two proteins interact if they bind at least 10% of shared compounds with a difference in potency of only 10-fold below an activity cutoff of 10 μM, and applied it in network analysis of drug –target interactions associated with asthma.
This study suggests a potential pharmacological interaction between PDE10A enzymes and drugs modifying DA neurotransmission.
Paolini et al. [13] identified different types of targets within the human pharmacological interaction network using Bayesian classification models.
We show that activity variation is a more suitable measure for characterization of the pharmacological interaction space than activity similarity.
The interpretation of the topography of pharmacological interaction space can vary according to the choice of measurement of c, s, d.
Furthermore, HLA-bound drugs are believed to occur through three different mechanisms via an altered repertoire complex, a pharmacological interaction (p.i).
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To determine in primary care the frequency of pharmacological interactions of statins.
Pharmacological interactions Triptans: an ergot derivate should not be administered within 6 h after the administration of a triptan.
Pharmacological interactions Anticholinergic drugs and antiacids may antagonize the effects of metoclopramide and domperidone on gastric motility.
The wide variety of drugs available for migraine prophylactic and acute treatment, and consequently their pharmacological interactions, might complicate the choice of a safe combination therapy.
To identify the pharmacological interactions of clinical relevance (PICR) in the medication authorisation cards (MAC) of the chronically ill and to establish strategies to minimise their appearance.
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