Sentence examples for pharmacological concentration from inspiring English sources

Novel contrasts can be obtained using a variety of agents, endogenous, natural, or artificially synthesized compounds (including, in recent studies, drugs at pharmacological concentration).

The normal physiological level of circulating RA in humans is estimated to be ≤10 nM and effective pharmacological concentration is >100 nM [38], [39].

This notion received further support from our observation that the pharmacological concentration of leptin (50 nM) promoted Ob-R/STAT-3 signaling while compromising cardiomyocyte contractile function, intracellular Ca2+ handling, NADPH oxidase expression, O2− accumulation, Akt/eNOS and stress signaling.

Most importantly, it did not inhibit, but instead stimulated FBS-induced HRE-Luc at pharmacological concentration (below 3  μM).

Melatonin at a pharmacological concentration (1 mℳ) decreases cellular and secreted VEGF levels, and prevents HUVECs tube formation under hypoxia, associated with a reduction in Hif1 α protein expression, nuclear localisation, and transcriptional activity.

For the high (pharmacological) concentration exposure (20 mg/L), a 2.5 g CFA/L stock solution was prepared in reverse osmosis (RO) water using 0.6 g/L NaOH in order to assist dissolution.

Conclusions: Pharmacological concentrations of 17β-estradiol retain the capability for relaxing omental artery rings from preeclamptic women.

We studied the effect of pharmacological concentrations of 17β-estradiol on potassium chloride-induced tension and the concentration contraction relationships for norepinephrine and calcium.

To elucidate the mechanism involved, effects of pharmacological concentrations of estrogen were studied in human ovarian cancer cell line 3AO cells.

Pharmacological concentrations of biotin enhance insulin secretion and the expression of genes and signaling pathways that favor islet function in vitro.

For example, TCPOBOP and estradiol activate mouse but not human CAR, and pharmacological concentrations of androstanol, progesterone, and testosterone repress mouse but not human CAR (Handschin and Meyer, 2003; Maglich et al., 2003).