Sentence examples for pharmacokinetic processes from inspiring English sources

Population pharmacokinetics is an approach to explain sources of variation in various pharmacokinetic processes across individual patient populations [ 22, 23].

In vivo the difference in activity between enantiomers or between diastereoisomers, may be due to the quality of the ligand-receptor fit, but also to differences in pharmacokinetic processes.

Modeling and simulation in pharmacokinetics has turned into the focus of pharmaceutical companies, driven by the emerging consensus that in silico predictions, combined with in vitro data, have the potential to significantly increase insight into pharmacokinetic processes.

Unfortunately, the majority of chemotherapy, which has a substantial hydrophobic component, is usually hampered by problems such as lack of tumor selectivity, poor water solubility, uncontrollable pharmacokinetic processes, and the possible incurrence of severe side effects [1 3].

QSAR (Quantitative structure-activity relationship) deals with descripting pharmacokinetic processes as well as biological activity or chemical reactivity [10], [11].

Doses are then estimated by using knowledge and assumptions about relevant pharmacokinetic processes.

In the present study the pharmacokinetic process of baicalin in normal rat blood and cerebral nuclei (cortex, hippocampus, striatum, thalamus and brain stem) was investigated with a newly established reverse-phase HPLC method after intravenous administration of baicalin-enriched Scutellariae Radix extract prepared according to the special protocol.

The result suggested that the DTX in two preparations can achieve a similar pharmacokinetic process in mice.

Here, we review the pharmacokinetic process of oral medication use, summarize the newer anticoagulants, their pharmacology, individual pharmacokinetic features, and explore possible explanations for the differences in bleeding outcomes observed in the clinical trials.

These data demonstrated that the DTX in Polysorbate 80 micelles and the DTX in Polysorbate 80/Phospholipid mixed micelles can achieve a similar pharmacokinetic process in rats.

In the pharmacokinetics assessment, there was no significant difference between the two preparations (P > 0.05), which demonstrated that the DTX in the two preparations may share a similar pharmacokinetic process.