Sentence examples similar to pharmacodynamic methods from inspiring English sources

Data are presented on pharmacodynamic (PD) method validation and preliminary clinical qualification of three PD biomarker assays.

Agreement between pharmacodynamic and pharmacokinetic methods of evaluating recovery from anaemia was assessed by Bland-Altman analysis [ 31].

In this tutorial, we explore the key issues that differentiate pediatric from adult pharmacokinetic (PK) / pharmacodynamic (PD) studies, describe methods to calculate the number of participants to be enrolled and the optimal times at which blood samples should be collected, and therapeutic drug monitoring methods for individualizing pharmacotherapy.

The current study was therefore undertaken to investigate the activity and cellular pharmacology of SG2000 in canine cancers in vitro, to assess the in vivo antitumour activity of SG2000 against canine tumour xenografts and to evaluate the potential of the comet and γ-H2AX foci methods as pharmacodynamic assays for use in the further clinical development of the drug.

Since many patients did not have parasite measurements recorded at 12 h, we performed a sensitivity analysis where we imputed parasite count at 12 h for patients with at least three parasite counts recorded in the first 24 h, including one of these measurements post 12 h (see "Methods," subsection "Pharmacodynamic measures" for details of imputation).

A prediction method of pharmacodynamic drug-drug interaction through protein-protein interaction networks is proposed in [ 94].

19 Methods for the pharmacodynamic and molecular analyses performed during the study are provided in the online supplemental material.

SG2000 also had significant in vivo antitumour activity against canine melanoma xenografts, and the comet and γ-H2AX foci methods were relevant pharmacodynamic assays.

As is evident from prior experience and emerging patterns of drug development, any future trial must incorporate tumor biopsies or novel methods to evaluate pharmacodynamic endpoints to guide patient and dose selection with Hsp90 inhibitor therapy.

Pharmacokinetic and pharmacodynamic parameters were calculated by noncompartmental methods and summarized by descriptive statistics.

Pharmacodynamic parameters were estimated using noncompartmental analysis methods.