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"There is a whole industry behind the industry," said Joseph Palo, a partner in the pharmaceutical strategy practice at PricewaterhouseCoopers in Florham Park.
Express Scripts, another large pharmacy benefit manager, is recommending that its clients not accept Pfizer's deals under the reasoning that it could cost more in the long run, according to F. Everett Neville, vice president for pharmaceutical strategy.
A common pharmaceutical strategy is the encapsulation of active substances to modify the release properties and the transport of a drug.
"They are setting up a Pfizer pharmacy, if you will," said Everett Neville, vice president of pharmaceutical strategy and contracting at Express Scripts., one of the nation's biggest pharmacy benefit managers.
Thus, although a low dose of resveratrol can improve quality of life by retarding aging parameters such as cardiac dysfunction, a nutritional or pharmaceutical strategy to also increase lifespan in mice will likely require blockage of the IGF-1 axis or its targets.
This pharmaceutical strategy offers the theoretical advantage of increasing drug efficiency while decreasing toxicity.
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Researchers warn against some of the most common pharmaceutical strategies for jet lag.
Carl Seiden, president of Seiden Pharmaceutical Strategies and a longtime industry analyst and consultant, said industry might be loath to wade in because Relenza and Tamiflu — two drugs that ameliorated flu but did not cure it — were huge commercial disappointments.
The present article presents and discusses the pharmaceutical strategies available to overcome poor water solubility in light of final drug product examples.
Five pharmaceutical strategies are currently approved by the US FDA for the treatment of obesity: orlistat, lorcaserin, liraglutide, phentermine/topiramate, and bupropion/naltrexone.
Pharmaceutical strategies to deter opioid abuse predominantly focus on tablet tampering, incorporating physical barriers (eg, crush resistance) or embedded chemicals that render tampered tablets inert, unusable, or noxious.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com