The microreactor team at Lonza has designed and tested a series of microstructured devices in continuous-flow plants, and performed lab studies of pharmaceutical reactions with successful transfer to commercial production.
During pharmaceutical syntheses, the reaction solvent has often to be switched off from one reaction step to the following one.
These biofilms were used to catalyse the biotransformation of 5-haloindole plus serine to 5-halotryptophan (Figure 1a), an important class of pharmaceutical intermediates; this reaction is catalysed by a recombinant tryptophan synthase TrpBA expressed constitutively from plasmid pSTB7 (Tsoligkas et al., 2011; 2012; Kawasaki et al. 1987).
Her clients have included Crayola, Pottery Barn, and Avon, and she's currently at work on a statistical survey for a pharmaceutical company, analyzing public reaction to different pill colors.
Two sensitive, selective, economic, and validated spectrofluorimetric methods were developed for the determination of ebastine (EBS) in pharmaceutical preparations depending on reaction with its tertiary amino group.
Two validated stability indicating spectrofluorimetric methods were developed for the determination of ebastine (EBS) in pharmaceutical preparations depending on reaction with its tertiary amino group.
This paper describes the design and synthesis of novel molecularly imprinted polymers (MIPs) for the selective removal of a potentially genotoxic impurity (GTI) from active pharmaceutical ingredient (API) post reaction streams.
What has happened to our Founding Father's dream of government, "Of The People, By The People, and For The People"? Now we are shocked again to learn that "in a 5-to-4 vote" the U.S. Supreme Court has struck down a lower court's ruling and award for the victim of a pharmaceutical drug's adverse reaction.
Acylation, particularly of amines, is the most frequently used reaction in pharmaceutical discovery, 7 and one of the most used reactions in the synthesis of drug candidates.
As there is often discordance between the naming of chemicals, especially those with pharmaceutical implications, a chemical reaction database and drug interaction database were not utilized for establishing chemical-chemical interactions.
