Danazol was formulated with polyvinyl alcohol (MW 22,000), poloxamer 407, and polyvinylpyrrolidone K-15 in a 2 1 1 1 weight ratio (40% active pharmaceutical ingredient (API) potency based on dry weight).
The U.S. Pharmacopeia (USP) publishes guidelines for the pharmaceutical industry for potency, stability testing, and storage, including temperature.
Despite their limitations, microbiological assays are widely employed to determine antibiotic potency of pharmaceutical dosage forms, since they provide a measure of biological activity.
As compounds are optimized for greater potency during pharmaceutical discovery, their aqueous solubility often decreases, making them less viable as orally-administered drugs.
SAFC Pharma, a member of the Sigma-Aldrich Group, is to undertake a US$30 million expansion of its Madison, Wisconsin facility, designed to significantly increase its capacity to produce commercial scale high potency active pharmaceutical ingredients (HPAPIs).
One of the advantages of using venom and poison toxins for pharmaceutical leads is the potency and highly targeted nature of the individual toxins.
The realisation that many of these toxins may have pharmaceutical and insecticidal potential due to their remarkable potency and selectivity against target receptors has led to an explosion in the number of new toxins being discovered and characterised.
A bioidentical hormone that has the same potency as a pharmaceutical manufacturer's hormone would, in all likelihood, have the same risks and benefits of the pharmaceutical hormone.
It was further demonstrated that these electrodes are able to analyze a pharmaceutical drug product of low potency, Miacalcic (8.3 μg mL−1), where no aggregation was observed.
This study demonstrates the power of C H oxidation in the field of drug discovery as a tool to improve not only the potency of a pharmaceutical lead but also its physicochemical properties.
