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TH and KO were responsible for the phantom preparations and helped with the study design.
JOD carried out phantom preparations, acquisitions, and reconstructions on both PET-CT and PET-MR scanning.
For each of the six phantom preparations, the phantom was scanned for a total of 16 min.
GM and BV conceived and designed the study; they carried out the phantom preparations and the activity measurements.
The same image quality phantom preparations were used for both system, to avoid different activity ratios between spheres and background, which may occur when preparing a phantom twice.
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With c mes the mean number of counts per voxel, T acq the acquisition duration (i.e., time per frame multiplied by total number of frames), C prep the prepared activity concentration, Δt the time between the phantom preparation and the acquisition, and T 1/2 the physical half-life of the radionuclide.
Fig. 2 Cell phantom preparation.
Fig. 1 Phantom preparation conditions for the warm background scans.
A detailed phantom preparation and imaging SOP is included in the Additional file 1 section.
Phantom preparation and PET/CT acquisition were performed according to the European Association of Nuclear Medicine (EANM) guidelines.
The images in Fig. 4 show images of the phantom for a 15:1 signal to background phantom preparation.
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