Arany, Z. PGC-1 coactivators and skeletal muscle adaptations in health and disease.
Scarpulla, R. C. Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network.
Lin, J. D. The PGC-1 coactivator networks: chromatin-remodeling and mitochondrial energy metabolism.
Wu, Z. et al. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1.
Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle.
PGC-1 is a potent transcriptional co-activator that mediates mitochondrial activity in response to insulin signaling20.
Thus, we proceeded to study the effect of parental PGC-1 depletion on heart function of the offspring.
Haemmerle, G. et al. ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1.
Specifically, heart dysfunction phenotypes of PGC-1XP heterozygotes (and of another PGC-1 allele) have previously been found to be the same as those of heart-specific PGC-1 knockdown16.
Lin, J., Handschin, C. & Spiegelman, B. M. Metabolic control through the PGC-1 family of transcription coactivators.
St-Pierre, J. et al. Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators.
