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Time for a Second Opinion, Harvard Health Letter, vol. 22, pg. 1 (November 1997).
We evaluated the receptors mediating sumatriptan hyperalgesia (1 pg, 1 and 10 ng).
Although Pg 1 and Pg 2 bind to 1-LN cells, only anti-TF antibodies inhibited the binding of Pg 1, suggesting that TF functions as the receptor for Pg 1 on 1-LN cells.
New York: Penguin Books, 1979, c1977, pg. 1. Post contributed by Janice Hansen.
Moreover, Pg 1 is not able to displace Pg 2 from the receptor.
Binding of Pg 1 to isolated TF was inhibited by 6-aminohexanoic acid and alpha-methylmannoside, suggesting that Pg 1 L-lysine binding sites and the biantennary, mannose-containing N-linked oligosaccharide chain are involved in this interaction.
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