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Only for absolute TRT of metabolic volume, significant lower values (p < 0.05) were observed for all registration strategies when compared to delineating VOIs separately, except for non-rigid PET registrations (p = 0.1).
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Using local PET registration, this number decreased to 40%.
Non-rigid PET registration provided good volume TRT (7.7%) that was smaller than the reference (16%).
Non-rigid PET registration showed the best performance (median DSC: 0.82, other methods: 0.71-0.81).
Figure 3 also shows a mismatch between CT and PET, causing CT registration to show less overlap between VOI and lesion than PET registration.
For semi-local rigid PET registration, one subject with a lung lesion showed a decrease in DSC (from 0.38 to 0.14) compared with global and local PET registration (Figure 3).
There was a mean of 61 min (range 50 to 70 min) between tracer administration and PET registration.
In case of non-rigid PET registration, however, all lung lesions showed a DSC of more than 0.59.
For small lesions (n = 16, < 35 ml), however, (local) rigid <span class="lh">PET registration and all CT registrations showed a significantly lower DSC (range: 0.44 to 0.65) compared to non-rigid PET and CTPET registration (0.79).
For all registration strategies, except non-rigid PET registration (p = 0.10), absolute TRT of metabolic volume (Figure 5C, Table 3) were significant lower compared to the reference (p < 0.05).
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