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The WL-MLEM algorithm with wobbling PET may offer improvements in both sensitivity and resolution, the two most sought-after features in PET design.
But as the creators of award-winning products like the Cubby coat hook, they have strong opinions about what makes for good pet design.
The PET design parameters have also been applied to the discovery of tritiated in vivo radiotracers.
A series of novel, water-soluble benzimidazolium salts with common 'fluorophore spacer receptor' PET design has been synthesized.
To identify better tracer leads, we started off by mining the data for existing chemical matter, prioritized by the CNS PET design parameters.
The first aim of this study is to show the potential of high resolution monolithic LYSO scintillator with SiPM readout for a compact Total Body (TB) PET design with only 3-4 thees the detector material of a current PET-CT scanner.
The prospective use of these PET design parameters was exemplified by the development of a highly selective PDE2A PET ligand 4- 3-[18F]fluoroazetidin-1-yl -7-methyl-5- 1-methyl-5- 4- trifluoromethyl phenyl -1H-pyrazol-4-yl)imidazo[1,5-f] [1,2,4- 3-[18F]fluoroazetidin-1-yl -7-methyl-5- 1-methyl-5- 4- trifluoromethyl phenyl -1H-pyrazol-4-yl
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The fully scalable concept overcomes the dilemma of sensitivity versus spatial resolution which is inherent to classical PET designs.
Strain induced crystallisation of poly ethylene terephthalate) (PET) designed for stretch-blow moulding is studied combining well-controlled tensile tests, different quenching protocols and X-ray diffraction technique.
The use of Geiger mode avalanche photodiodes (G-APD /micro-cell APDs (MAPD) opens new simplifications in Positron Emission TomoG-APD /micro-cellG-APD /micro-cell
Five PET samples were used: commercial virgin PET, designed for bottle production (BPET); virgin PET taken from the first stage of condensation polymerization, similar to fiber grade PET (FPET); PET flakes from post-consumer soft drink bottles (RPET); RPET composite containing 30 wt% of fiberglass (RPETComp) and RYNITE®, a commercial PET composite containing 30 wt% of fiberglass.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com