As disulfide exchange between PDI family members is pervasive, these observations suggest that a more reduced ER poise would favor re-uptake of calcium into the ER and disfavor its release.
"The situation is very different for the oceans," Dr. Knowlton and Dr. Jackson wrote, because degradation of ocean ecosystems is so pervasive, and underwater observation is relatively recent.
This observation supports pervasive ongoing positive selection through 40,000 generations in these experimental populations (Barrick et al. 2009).
A significant application of this theoretical model exists in the observation of pervasive whole-cell adaptations in selected ion channels (I Na, I CaL) after cocaine sensitization, with implications of the type of learning that underlies addiction.
The observation of pervasive removal of 5mC from gene bodies adds a new dimension to our understanding of methylation reprogramming, which up to now has centered on promoters and CGIs.
On the basis of our observation of pervasive backbone motions on the microsecond time scale in human DHFR, it seems highly likely that catalytically relevant motions in the human enzyme are much faster than in E. coli DHFR.
Particularly for ChIP-Seq studies, our observations of the pervasive inhomogeneity of coverage in the input sample highlighted the need to normalize the sequence read counts from ChIP samples to the input control counts.
And that observation is consistent with other pervasive falsifications of biblical history in Medieval and Renaissance artworks which convert Jesus, his family, and close followers into Medieval and Renaissance Christians, without providing even a hint of their Jewish heritage and identities.
Because of pervasive gene duplication in the angiosperms, the observation of hundreds of shared single copy nuclear genes in the sequenced genomes we have examined raises interesting biological questions.
One observation is simply that punishment is pervasive.
