These data suggest that the swd mutation perturbs the function of Trpm7 in regulating cellular Mg2+ levels, causing upregulation of p21 cdkn1andnd cyclin G1 mRNA and leading to impaired growth of exocrine pancreas.
Yet cells seem to be able to maintain their normal functions despite many perturbations, such as the gene knock-out or DNA mutations perturbing the functions of proteins, while being sensitive to some specific attacks (Jeong et al., 2001).
(3) It still remains unclear whether binding of TALE or Cas9 gRNA complex to the target sites would perturb the function of the native DNA-binding proteins and cause unwanted perturbation of cellular function.
Rapid and reversible methods for perturbing the function of specific proteins are desirable tools for probing complex biological systems.
Organic small molecules generally act by perturbing the function of one or more cellular target proteins, the identification of which is essential to an understanding of the molecular basis of drug action.
When compared to traditional genetic mutations, they have the advantage that they can be used to reversibly perturb the functions of molecules at different points of embryonic development or disease progression.
EDCs could, potentially, perturb the function of each of the cell types involved.
Fusion of proteins can sometimes perturb the function of the individual components.
These therapeutic RNA decoys and aptamers block HIV-1 transcription by perturbing the function of TAR.
The presence of oxidized and highly aggregated lipid within lysosomes has the potential to perturb the function of these organelles and to promote atherosclerosis.
