Moreover, perfluorooctane sulfonic acid perturbs the functioning of motor neurones by altering α-Tubulin and proliferating cell nuclear antigen.
(3) It still remains unclear whether binding of TALE or Cas9 gRNA complex to the target sites would perturb the function of the native DNA-binding proteins and cause unwanted perturbation of cellular function.
Rapid and reversible methods for perturbing the function of specific proteins are desirable tools for probing complex biological systems.
Organic small molecules generally act by perturbing the function of one or more cellular target proteins, the identification of which is essential to an understanding of the molecular basis of drug action.
EDCs could, potentially, perturb the function of each of the cell types involved.
Fusion of proteins can sometimes perturb the function of the individual components.
These therapeutic RNA decoys and aptamers block HIV-1 transcription by perturbing the function of TAR.
The presence of oxidized and highly aggregated lipid within lysosomes has the potential to perturb the function of these organelles and to promote atherosclerosis.
Thus far, the most frequently used technology to perturb the function of uncharacterized proteins is the use of antisense morpholino oligonucleotides.
Mutation of tyrosine to tryptophan minimally perturbed the function of pol β as examined by its CD spectrum and enzymatic activity.
