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Kim et al. (2004) assayed for perturbed heart development by scoring injected embryos as wild-type or mutant with respect to the expression of the d-Mef2-lacZ transgene.
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Loss of nexilin (encoded by nexn) in zebrafish led to perturbed Z-disc stability and heart failure.
Disruption of the dyad architecture results in partial uncoupling of the geometric relationship between two of the protein components governing CICR: the sarcolemmal LTCCs (L-type voltage-gated calcium channels) and RyRs (ryanodine receptors) in the jSR, resulting in perturbed Ca2+ dynamics, which is a hallmark of heart failure [ 5].
Concerning the metabolism status, it has been demonstrated that rodents with natural inborn low aerobic capacity harbour an altered and perturbed energy metabolism and an enhanced oxidative stress in heart proteome [ 112].
But it will not still the fears of those most perturbed by what is happening to the creativity cluster at the heart of the capital, whose main avenue Denmark Street has been for a century.
It has been suggested that normal heart behaviour might be chaotic and can thus respond efficiently to perturbed conditions, whereas diseased hearts are more stable in their frequencies and less able to make necessary adjustments to stress [18].
The additional phenotype of congenital heart defects observed in some affected males could be due to perturbed NHS gene transcription or increased dosage of the NHS, SCML1 or RAI2 genes.
I remain a little perturbed.
Others are just plain perturbed.
You may be confused, or perturbed.
"Don't get perturbed," he said.
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