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For each contrast, Table 2 presents the number of processes, the number of cross-annotating pairs among these processes, the number of interactions which the process pairs cross-annotate, and the number of those interactions which we consider "perturbed" (i.e., both interacting genes exhibit perturbed expression for that contrast; see the section titled "The MCMC-BPN algorithm" for details).
Genes whose expression is particularly sensitive to mutation were more likely to exhibit perturbed expression when other genes were deleted, and exhibited greater sensitivity to environmental perturbation (Landry et al. 2007).
Emerging evidence has indicated that the perturbed expression of homocysteine (Hcy) may induce mitochondrial dysfunction and disturb bone metabolism.
We observe an increase in the perturbed expression of CYP27A1 concomitant to but lagging that of Lrh-1 (Nr5a2).
In the present study we also found perturbed expression of Raldh3/Aldh1a3 in Pax6 heterozygous lens (see Fig. S3); however in the opposite direction.
At 6 hours post induction, 10 gene deletion mutants (N = 10) displayed perturbed expression of Pot1p-GFP (Figure 1 and Table S1-2).
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The Lewis chessmen, a set of vividly carved walrus-ivory figures with perturbed expressions and elaborate garments, were discovered on a remote, salt-bitten Scottish island in the nineteenth century.
We found that of the 13 selected genes analyzed, 11 (the two exceptions are DDM1 and AGO4-2) significantlyicantly perturbed expressions in the mutator-phenotype (Tong211-LP) relative to its rice parental line (Tong211).
We tested the algorithms in an analysis of the p53-perturbed expression profiles (Subramanian et al., 2005).
We labeled mouse orthologs of genes with BPDE-perturbed expression (FDR <0.05) as "secondary" since BPDE does not bind Ahr, but indicates affected genes further downstream of Ahr.
The area of perturbed Bmp4 expression is outlined.
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