CLD develop in the interface between genetic susceptibilities and environmental aspects, initiated and perpetuated by ill-defined lung injury and failed repair mechanisms, and ultimately lead to perturbed lung architecture incompatible with normal respiratory function.
This has been demonstrated by altered crypt/villus architecture, perturbed cell migration, increased cell proliferation and apoptosis, as well as altered gene expression [ 37].
The observation of reduced compaction between the two intervals on chromosome 13, viewed in light of the overall reduction in chromosomal volume, suggests perturbed and uneven chromosomal architecture with the LMNA mutation.
Thymic architecture is severely perturbed following endotoxin challenge, with damage to thymus epithelium and visible remodeling of thymic morphology, involving loss of distinct cortico-medullary junctions [7], [8].
Deletion of the Mip gene in mice disrupts the formation of sutures, which are required for maintenance of the lens fiber architecture, resulting in perturbed accommodation and focus properties of the ocular lens (Shiels et al., 2001).
The outcome is a generalized cellular lipid dyshomeostasis and consequently, the physiological architecture of the lipid-enriched plasma membrane is perturbed, including the lipid composition of specialized membrane microdomains, often termed lipid rafts.
This information gain can be used to choose those genes that will be perturbed in subsequent experiments in order to refine our knowledge about the architecture of an underlying gene regulatory network.
As such, tools that enable closed loop experiments in which freely moving animals can be precisely perturbed, either neurally or mechanically, will improve our ability to probe the locomotor control architecture.
Janet Evans was less perturbed.
