The first involves perturbation of component modal properties which can be related to perturbations in the modes of the assembled structure and hence to the energies and CLFs.
Genetic variation in undomesticated tree populations provides abundant perturbation of systems components, adding another dimension to plant systems biology (besides spatial and temporal variation).
Each of these responses is activated following perturbation of particular components of the envelope.
In silico perturbation of network components also captured biological features of cytokine interactions (antagonism, synergy, redundancy).
A more recent study focused on perturbation of other components of the yeast transcriptional apparatus, in particular the chromatin machinery (Lenstra et al. 2011).
Many gene expression networks contain negative regulatory loops that act to restore expression to physiological levels upon perturbation of pathway components (Becskei and Serrano 2000).
Chemical inhibition of these non-canonical signaling pathways including JNK or perturbation of their components alters EMT, suggesting their important function during epithelial to mesenchymal transition (Santibanez, 2006; Alcorn et al, 2008; Liu et al, 2008; Gui et al, 2012).
Since the authors have access to the lamin mutant mice and flies with specific perturbation of Ne components, figure (a) showing the circadian behavior phenotype of these animals will substantially strengthen the manuscript.
Perturbation of Wnt components suppresses the seam defects associated with ceh-16 mutants, suggesting that ceh-16 may act as an upstream regulator of the Wnt pathway (Huang et al., 2009).
We present evidence that a major aspect of the mechanism of acute signal transduction regulation by insulin-like growth factor-1 (IGF-1) in cultured murine myoblasts is associated with a broad perturbation of many components of cholesterol and fatty acid biosynthetic pathways.
