The magnitude of perturbation (amount and speed of sudden treadmill belt motion) was set for each trial by the therapist from level 1 (mildest) to level 5 (most vigorous) based on each patient's day-to-day and trial-to trial performance.
The dynamic behaviour of iron in the cLIP related to ferritin activity in response to a perturbation in the amount of labile iron is shown in Figure 6.
With respect to the possible impact of the extrinsic noise in IAP, we simulate the stochastic model with additional perturbation in the amount of IAP protein.
MCA focuses on how the NESS { x i ∗ } shifts in response to a perturbation to the amount of enzyme for a reaction or a perturbation to its substrate (∈ I ) concentration.
We found only 4 additional conserved blocks from such local alignments (e-value < 10-6), whish is again only a minor perturbation to the total amount of predicted functional sequence.
The logical approach further allows an easy, systematic analysis of perturbations, which amount to keeping a variable to its lowest levels (loss-of-function experiment) of to its positive levels (gain-of-function experiment).
It also calculates a gamma P value using the perturbation factor for each input gene in the pathway that accounts for the normalized fold change of the gene and the number and the amount of perturbation of genes at downstream positions on the pathway.
Pathway Express calculates an Impact Factor (IF) which is used to rank the affected signaling pathways, based on the fold change, the number of the involved genes in the pathway, and the amount of perturbation of downstream genes [ 31].
Impact Factor (IF) is used to rank the affected signaling pathways, based on the fold change, the number of the involved genes in the pathway, and amount of perturbation of downstream genes.
Consequently, the change in an upstream response necessary to produce an adverse apical response may depend on the baseline response, and it could reasonably be the case that no single amount of perturbation of a biochemical or genomic response will be without risk for all members of a population.
We then tried to knock down the parABm operon in order to test whether a perturbation in the amounts of ParAm and/or ParBm would yield a detectable phenotype, and also to pinpoint which of the two ORFs is essential.
