Sentence examples for perturbation in the expression of from inspiring English sources

Homozygous Nbn null mutant mice, however, showed a much greater and prolonged perturbation in the expression of these proteins.

As a notable component of the G-2 GRN we identified the transcription factor Sox10, known as a glial and neural crest cell fate regulator [76], and demonstrated that perturbation in the expression of a single component of the GRN can significantly influence the composition of the CCS.

Cancer can originate from perturbation in the expression of positive or negative regulators of cell cycle machinery leading to abnormal proliferation of cancer cells [ 29].

To monitor a potential perturbation in the expression of cardiomyocyte-specific markers, we looked at the expression levels of cardiac vmhc and of cardiac cmlc2 in 2-day MO1 Fam40b knockdown embryos.

Bcl-2 family of proteins has critical role in the regulation of mitochondrial-mediated apoptosis, and perturbation in the expression of these genes trigger a variety of biochemical changes.

Such perturbation in the expression of both proteins are likely to contribute to the resistant phenotype since these cells require the mitochondrial amplification loop for efficient induction of anti-CD95 and TRAIL-induced apoptosis.

In general, we expect that deep sequencing methods will better detect perturbations in the expression of genes encoding transcription factors and signaling proteins, which tend to be expressed at lower levels than other genes in the cell [68].

Therefore, identifying perturbations in the expression of synaptic gene products within CA1 neurons prior to frank AD is crucial for the development of disease modifying therapies.

Interestingly we found a new level of regulation: perturbations in the expression of miRNAs can affect the expression of other miRNAs, indicating that miRNAs might act as in networks.

In contrast, our microarray analyses documented progressive perturbations in the expression of a large number of genes that do not carry U12-type introns, suggesting that defective U12-type intron splicing leads to significant downstream effects on genes that do not contain U12-type introns.

Previous studies have identified perturbations in the expression of MHC class II genes in patients with CFS.