Sentence examples for perturb the function of from inspiring English sources

(3) It still remains unclear whether binding of TALE or Cas9 gRNA complex to the target sites would perturb the function of the native DNA-binding proteins and cause unwanted perturbation of cellular function.

EDCs could, potentially, perturb the function of each of the cell types involved.

Fusion of proteins can sometimes perturb the function of the individual components.

Hyperinsulinemia is also known to perturb the function of neurotransmitter systems [ 61] and has been shown to have direct effects on hippocampal synaptic plasticity [ 62].

Thus far, the most frequently used technology to perturb the function of uncharacterized proteins is the use of antisense morpholino oligonucleotides.

The presence of oxidized and highly aggregated lipid within lysosomes has the potential to perturb the function of these organelles and to promote atherosclerosis.

When compared to traditional genetic mutations, they have the advantage that they can be used to reversibly perturb the functions of molecules at different points of embryonic development or disease progression.

For example, if the oxidant does not perturb the functions of the noncatalytic domains of RasGEFs, the oxidant will continue to inhibit the catalytic action of Cdc25 on wt Ras.

Although SGTP has been observed to bind to a broad spectrum of CDKs, it is possible that CDKs may be able to employ SGTP, in a similar manner as ATP, as phosphate donor to phosphorylate its substrate proteins, which may not perturb the functions of CDKs.

Rapid and reversible methods for perturbing the function of specific proteins are desirable tools for probing complex biological systems.

Organic small molecules generally act by perturbing the function of one or more cellular target proteins, the identification of which is essential to an understanding of the molecular basis of drug action.