Sentence examples for perturb the development of from inspiring English sources

Reduction of GABAergic inhibition after eye opening has been shown to perturb the development of cortical columnar architecture [64].

In order to identify a higher proportion of compounds with interesting biological activities, we screened a diverse synthetic library for compounds that perturb the development of any of the multiple organs in zebrafish embryos.

We have demonstrated that the causative mutation of HSAN1, SPT1 C133whenexpressedsed in Drosophila (as dSpt1C129W) acts dominantly to reduce sphingolipid synthesis, generate synthesis of DSBs and perturb the development of dendrites, neuromuscular synapses and nociceptive function of the class IV da sensory neurons.

Expression of T-Ag did not perturb the normal development of the mammary gland and no mammary tumours were observed in this, or in any of the lines, despite T-Ag being present.

Thus arterial wall proteoglycans play a major role in cell adhesion and function [64], processes that are perturbed during the development of atherosclerosis.

Tian et al [ 15] demonstrated that NCC-specific inactivation of p120 catenin mice perturbs the proper development of certain eye structures and causes anterior segment dysgenesis, including adhesion of the iris to the cornea, hypoplasia of iris and ciliary body, and dysgenesis of cornea, trabecular meshwork, and Schlemm's canal.

That such low concentrations of BPA could perturb the timing of fetal brain-cell development suggests that existing regulatory practices might miss some of the effects of endocrine-disrupting chemicals such as BPA, the authors said.

The integrated data analysis leads to the identification of how biological networks are perturbed by the exposure and enables the development of predictive mathematical models of toxicological processes.

The development of strategies to perturb niche components has provided insight into the responsive nature of the niche and offers a framework to uncover how disruption of a normal stem-cell niche function may contribute to the onset of the ductular reaction and its progression.

When compared to traditional genetic mutations, they have the advantage that they can be used to reversibly perturb the functions of molecules at different points of embryonic development or disease progression.

It is therefore possible that methylation-induced silencing of HOXD3 is perturbing TGFβ signalling, and perhaps contributing to the development of high grade PCa.