Sentence examples for perturb the development from inspiring English sources

Reduction of GABAergic inhibition after eye opening has been shown to perturb the development of cortical columnar architecture [64].

In order to identify a higher proportion of compounds with interesting biological activities, we screened a diverse synthetic library for compounds that perturb the development of any of the multiple organs in zebrafish embryos.

We have demonstrated that the causative mutation of HSAN1, SPT1 C133whenexpressedsed in Drosophila (as dSpt1C129W) acts dominantly to reduce sphingolipid synthesis, generate synthesis of DSBs and perturb the development of dendrites, neuromuscular synapses and nociceptive function of the class IV da sensory neurons.

Expression of T-Ag did not perturb the normal development of the mammary gland and no mammary tumours were observed in this, or in any of the lines, despite T-Ag being present.

Tian et al [ 15] demonstrated that NCC-specific inactivation of p120 catenin mice perturbs the proper development of certain eye structures and causes anterior segment dysgenesis, including adhesion of the iris to the cornea, hypoplasia of iris and ciliary body, and dysgenesis of cornea, trabecular meshwork, and Schlemm's canal.

Defining the temporal and spatial expression patterns of genes that specify the phenotype of corticospinal neurons will be invaluable in understanding how lesions and infections can perturb the protomap during cortical development and how to produce corticospinal neurons from stem cells for the repair of brain following neonatal hypoxia or adult stroke.

Thus arterial wall proteoglycans play a major role in cell adhesion and function [64], processes that are perturbed during the development of atherosclerosis.

Not least of these was the discovery that perturbing the process of development often resulted in a freak show starring horrors like bipedal goats and insects with legs growing out of their mouths, monstrosities that seemed to shed little light on the wonders of evolution.

Therefore, to investigate the TrkA signal in intra-adipose sympathetic plasticity without perturbing the normal sympathetic development, we exploited the chemical-genetic approach of TrkAF592A/F592A mice.

Mutation of Pax3 in Splotch mice perturbs the neural crest affecting development of various structures including the outflow septum of the heart [ 21, 22, 52].

As a result, the limiting factor is perhaps no longer the difficulty in establishing methods to perturb heart development; rather it is the challenge of integrating the burgeoning data from diverse studies of gene expression, cell lineage, proliferation and tissue architecture.