Sentence examples for perturb the ability from inspiring English sources

Taken together, these results indicate that cancer predisposition alleles that are DNA damage sensitizing may also perturb the ability of the DNA repair pathways to elicit CSR.

In contrast, the S298E mutation, which had no effect on either cofactor-activated phosphorylation or affinity for chromatin, did not perturb the ability of Gro/TLE1 to inhibit neuronal differentiation (Fig. 7B E, cf. bars 2 and 8).

In summary, these data support the idea that many of the mutations identified in this screen perturb the ability of an ommatidium to make the early decision to produce a single R3 and a single R4 photoreceptor.

Of the 175 regulators identified in the fatty acid utilization studies, we identify a subset of regulators (8 genes (5%)), in which peroxisomes appear to be wild type with respect to Pot1p-GFP levels and peroxisomal morphology, that exclusively perturb the ability of S. cerevisiae to utilize fatty acids.

We were able to assess the role of cofactor-activated phosphorylation by taking advantage of the demonstration that the SP domain mutations characterized in this study block this hyperphosphorylation event but do not perturb the ability of Gro/TLE1 to functionally interact with DNA-binding proteins and become recruited to DNA.

Finally, we provide evidence that DLK depletion does not perturb the ability of C/EBPβ to bind to the c/ebpα and pparγ2 promoters, indicating that DLK acts upstream of the master adipogenesis regulators C/EBPα and PPARγ2 but downstream of their activator C/EBPβ.

Second, lead may directly alter bone cell function by perturbing the ability of bone cells to respond to hormonal regulation.

These studies suggest that the mutations may affect substrate binding, thus perturbing the ability of PP2A to dephosphorylate particular protein substrates.

This is because mutation of the ECM-binding sites has significantly perturbed the ability of PR/NMB to bind to all three ECM components.

All enzyme forms retain essentially full succinate-oxidase activity in the succinate-PES assay, indicating that the amino acid substitutions have not perturbed the ability of the enzyme to oxidize succinate and that the enzyme is fully assembled.

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