Sentence examples for perturb development from inspiring English sources

In order to determine if stability of the Bcd gradient prior to cellularization is essential for pair-rule patterning, here we use a microfluidic device to perturb development with a temperature step [12], [13] and modulate both nuclear divisions and the Bcd gradient.

The three RTK-DN mutants used in this paper have been employed by many groups to perturb development of a variety of different tissue and organs in Drosophila.

It is thus important to identify and develop new molecules that can overcome the limitations of the present drugs and perturb development of antibiotic resistance by mycobacteria.

As most embryos donated for human ESC derivation were cultured in relatively simple media, now known to perturb development, before being frozen at the precompaction stage up to 10 years earlier, we examined the hypothesis that the period where they are subsequently cultured to the blastocyst stage could be exploited to improve the efficiency with which cell lines could be derived.

While the core of the machinery implicated in RAS signalling has been characterized comprehensively, signal propagation through this network is likely to include a larger number of proteins playing a modulatory or structural role (14), whose aberrant or defective function is expected to perturb development and contribute to oncogenesis.

All Sox2-siRNA duplexes were effective in perturbing development; by day 5, Sox2-duplex-1 had led to developmental arrest of 24% of embryos at the 4-8-cell stage and 51.7% at the morula stage.

Thus, ectopic expression of Runx2 perturbs development and differentiation in the mouse mammary gland, suggesting that levels must be tightly controlled for normal development.

In Drosophila, it is expressed primarily in the nervous system, and a P-element insertion next to the gene perturbs development of the peripheral nervous system [ 46, 47].

AuNPs with both positive and negative charges perturbed development significantly, with positively charged AuNPs primarily causing mortality and negatively charged particles inducing malformations.

Genes that contribute to cancer frequently have crucial roles in embryonic development; therefore, elucidating the mechanism by which EWS-FLI1 perturbs development will also shed light on its contribution to tumorigenesis.

Ethylene glycol and ethylene glycol monomethyl ether were shown by both standard evaluations in mammals, and by the hydra assay, to disrupt embryos only at or very near to their respective adult toxic doses, whereas the mono-ethyl ether perturbed development at approximately one-fifth of the lowest dose overtly toxic to adults.