As found by Kennedy et al. [ 7], the items that relate to more than one factor are mainly associated with symptoms, thus reviving the debate whether these items should be considered separately to those pertaining to functioning.
A cluster with more diverse levels, such as 8, contained proteins pertaining to hypothetical functions, with high values of %chSp (Additional file 4).
As EVD was not considered a high research priority until now, there is lack of integrated knowledge pertaining to gene functions, protein interactions, available literature and activities of binding ligands.
It includes questions pertaining to autonomic functions such as rest/activity rhythms, vertigo, orthostatic regulation, heat regulation, metabolism and digestion; additional questions on activity aim to record self-reported sleep duration and quality, as well as day-time functioning which could reflect the rest/activity rhythm [ 12].
Indeed, the majority of recent studies focussing on the relationship between ageing and the gut microbiota used a 16S rDNA amplicon sequencing approach, which reflects the phylogenetic structure of the microbiota but does not provide information pertaining to function.
Based on these discussions, information components were classified into two parts, namely (a) information pertaining to functioning and disability as understood by the ICF-CY (basic assessment), and (b) information pertaining to requirements as conceptualised in the expanded ICF-CY model (assessment of requirements).
To shorten the time needed for questionnaire completion, we suggest excluding the SF-36 questions pertaining to physical function, as this part would be covered by the IOF QLQ.
The results pertaining to sexual function were already reported [Br J Cancer 82(2) (2000) 282].
Major challenges in analyzing the multitude of data pertaining to the functioning of the organ systems over time are to extract meaningful clinical patterns and to provide predictions for the future course of diseases.
First, we find that the genotypic differences are highly concentrated in genes pertaining to neuronal function.
