Exact(1)
Using the method described here, we quantified miRNA activity in papillary thyroid carcinoma and breast cancer, and found a strong and distinctive signal of increased global miRNA activity, embedded in the pertaining gene expression measurements.
Similar(59)
For this reason, we attempted to determine the overall effect of miRNAs on their target genes, their biological activity, and designed a method for measuring this effect directly from the pertaining target gene expression levels.
Two separate datasets have been used to test our model-based approach, both pertaining to gene expression changes derived by specific genetic alterations in cancer.
These include genome-scale collations of data pertaining to gene expression, protein-protein interactions, genetic interactions and intra-population genomic polymorphisms.
Due to the progress in -omics studies and bioinformatics, including computer simulation, we can now integrate knowledge from different levels such as that pertaining to gene expression, protein expression, and metabolite concentrations.
There were 98,561 annotated interactions pertaining to phosphorylation, gene expression and physical binding events that mapped to siRNA targeted genes.
Revealing the regulation mechanisms of gene expression pertaining to temperature has attracted tremendous efforts in recent years particularly owning to the yielding of transcriptome and proteome data by high-throughput techniques.
However, these studies have produced limited data pertaining to post-SCNT gene expression changes.
An overall picture of the general trend of changes in gene expression pertaining to the 14 KEGG pathways that characterize the transition of the preterm versus term uterus is summarized in Figure 2. Drawbacks and limitations inherent to the use of Onto-Tools or of their cognate alternatives for ontological analysis have been discussed.
The module expression coherence is defined as the average of Pearson correlation coefficients of all pair-wise gene expression profiles pertaining to the corresponding module across the 29 common tissues.
We further identified 4 datasets from the Gene Expression Omnibus pertaining to rodent models of neuropathic pain.
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