Exact(4)
We present and discuss some of the basic concepts and assumptions of this perspective on evolutionary medicine.
Genomic recurrence provides a new perspective on evolutionary processes, informing us in often unexpected ways about commonalities of forces mutational and/or selectional acting across different lineages.
Codon usage studies retain some of the underlying structure of the coding sequences in the comparison and may give another perspective on evolutionary changes.
Although the tools here applied were not originally designed for large scale phylogenetic analysis, we adapted them to work on a large scale, since we strongly believe that a system-wide perspective on evolutionary processes can greatly improve the understanding on how genomes came to be and what evolutionary process took them there.
Similar(56)
Within the past decade, local fitness landscapes have become experimentally tractable and are providing new perspectives on evolutionary mechanisms.
While the body of work in this area is immense, we wish to focus attention on two concepts that represent core perspectives on evolutionary causation and have direct relevance to undergraduate science educators: natural selection and genetic drift (Table 1).
[Abstract available: http://onlinelibrary.wiley.com/doi/10.1002/tea.20384/abstract] Modern college-level biology textbooks include diagrams that depict both cladogenic (branching events) and noncladogenic or anagenic (ordered linear progressions) perspectives on evolutionary history.
However, this perspective of evolutionary history, based on living organisms alone, is an artifact.
Other non-recombining regions in the human genome, as they are identified, can likewise be explored for phylogeographical studies, each one providing a fresh perspective on human evolutionary history.
Our analysis of the evolutionary consequences of phenotypic damage complements these studies and provides a new perspective on the evolutionary origin of aging.
This surprising discovery offers a new perspective on the evolutionary origin of the freshwater eels and may provide novel insights into the evolutionary process of their unique catadromous migrations.
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Justyna Jupowicz-Kozak
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