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From a teleological perspective, alterations in both intermediary metabolism and its control are not surprising insofar as highly proliferative cancer cells exhibit increased energy demands and expanded requirements for macromolecular precursors to support nucleic acid and protein biosynthesis, as well as membrane biogenesis, for increased biomass.
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These traits are important from a life-history perspective, and alterations to their frequency as a result of fishing-induced selection could alter fish population structure.
In this new perspective, flow alterations due to different cardiovascular procedures can affect the long-term outcome of those procedures.
From a translational perspective, bioenergetic alterations in monocytes and lymphocytes are also linked to their changing biology during the progression of the inflammatory process [ 28, 29].
Functional similarities between membrane blebs that mediate bacterial internalization and tumor metastasis have not previously been realized, and awareness of these similarities provides a new perspective on alterations in membrane properties that occur in association with tumor metastasis.
Apart from its intrinsic biological interest, the analysis of the centromere is also relevant from a biomedical perspective, as alterations in centromere function lead to aneuplody (gain or loss of chromosomes) that most frequently results in lethality.
The DOHaD hypothesis proposes, from a broad perspective, that alterations in the intrauterine environment can affect the developing fetus in a number of aspects including organogenesis, cell differentiation, and lipid and glucose metabolism, thereby altering risk for development of a range of cardiometabolic disorders in later life [ 26].
From another perspective, this alteration can be viewed as a biological process in which the common unifying features are cellular hyperplasia resulting in enlargement of lobules.
From a network perspective, each alteration affects feedback within the pathway: constitutively expressing or deleting the transporter genes disrupts positive feedback, whereas deleting the catabolic genes disrupts negative feedback.
Using this metric, we found the PDGF pathway provides highly significant p-values (P-value: 0.01) when considered from a copy number alterations perspective.
This investigation adopts a new perspective on wettability alteration as a function of temperature.
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CEO of Professional Science Editing for Scientists @ prosciediting.com