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This study examined the association of emerging late-onset depression (LOD) and AD with plasma Aβ42 in a sample of never depressed and not demented persons at baseline.
Finally, most of the events occurring during simulations being stochastic, we used a large sample size (675,000 persons at baseline, or about 12% of the total population) in order to reduce variability in the results of simulations.
Of the 3,326 persons at baseline, 647 had died and 197 were lost to follow-up.
This recruitment resulted in a quite healthy and robust cohort of elderly persons at baseline (n = 3,326).
The intervention group comprised 56 persons at baseline, 44 persons at follow-up 1 (79%) and 42 at follow-up 2 (75%).
Analyses for this study included only non-demented persons at baseline, as ascertained by in-person evaluation, who had at least one follow-up over 4 years.
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"I've always been a very emotional person at baseline," she said.
Each participant was assessed in-person at baseline and is assessed every other year thereafter (Fig. 1).
Demographics and clinical outcomes were collected in person at baseline and six months.Approximately 87% of subjects completed wbPROs without assistance, and wbPROs strongly correlated with standard PROs (r>0.91).
All 1341 participants were seen in person at baseline.
All data were collected in person at baseline with assistance as needed, and by mail three and six months later.
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