Sentence examples for personal mutation from inspiring English sources

Many of the government's most contentious ideas, such as planning reform, the benefits cap and regional pay in the public sector, are his projects.Several things brought about this personal mutation.

These data, assessed from the perspective of individual patients, provide one of the first glimpses of personal mutation profiles and establish a foundation to elucidate the disease significance of these variants in future next-generation sequencing analyses of PIBD patients.

In the early 2000s, every living participant in the gene-identification studies was invited to participate in a phenotyping study, which included detailed phenotype characterization and mutation testing, but no participants were aware of the presence of the p16 mutation in their family or their personal mutation status (24).

Occurrence of variants in the reconstructed mitochondrial genomes was not exclusive for a particular world area, but generally a variable number of samples belonging to different populations shared the same homoplasmic and quasi-homoplasmic/highly heteroplasmic variants, while low-level heteroplasmies were detected only in single individuals and may hence be likely considered personal mutations.

Antoniou et al (personal communication), using mutation and family history data from a large population-based series of breast cancer patients from East Anglia, UK, have shown that a variety of both single gene and polygenic models can give an adequate fit once BRCA1 and BRCA2 are allowed for.

Such increases have been also observed in patients with the ITD-FLT3 mutation (Shults, personal communication).

15, 44, 45 It is possible that our series is subject to a referral bias because patients with known mutation or personal or family histories of syndrome-related tumors were more likely to be recognized and included in this study.

We expect that ambiguous personal susceptibility on PRNP mutation causing fCJD can be defined through further studies of combined interpretation of biological network analysis derived from next-generation sequencing of individual genomes and clinical information.

Wessels and coworkers [ 56] identified 33 out of 34 proven BRCA1 cases and assigned 10 false-positives among bilateral breast cancer cases (enriched for elevated risk), four of which have since been proven to be true BRCA1 mutation carriers (personal communication).

We proposed a novel method for listing long approximate STRs with mutations in personal genomes using a massive number of short reads of length ∼100 bp.

The overall procedure for computing the closeness is as follows: Step 1. Quantify damaging missense mutations in personal genome sequences using the Sorting Intolerant From Tolerant (SIFT) tool [ 17].