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The persisting activity of LynB after LynA degradation is likely to activate negative feedback responses and ensure deterioration of membrane-proximal signaling.
An important question that remains is whether higher cortical areas, particularly those with fast response latencies (such as V5/MT or FEF) play a role in generating the persisting activity in areas V2, V3 after V1 lesions.
In contrast to irinotecan, ST1968 still showed an excellent, persisting activity in models less susceptible to apoptosis induction (KB, Caski and SiHa), in which drug treatment elicited a persistent DNA damage response, as documented by phosphorylation of p53, RPA-2 and histone H2AX, resulting in delayed apoptosis and senescence.
Conversely, memory in the primary pathway is automatically gated off once the primary stimulus disappears and thus any residual response must reflect persisting activity in the secondary pathway [ 2, 138].
Similar(56)
Furthermore, intra-osseous tumor growth of noggin-silenced PC-3 cells was limited, most probably as a result of the persisting osteoblast activity.
In accordance with our data, persisting clinical activity was expressed with arthralgias or fever.
Patients with persisting disease activity require treatment with disease-modifying antirheumatic drugs (DMARDs) [ 17].
In contrast, all patients with PCR had persisting biological activity (Table 2).
At the end of follow up, high ferritin levels and anemia were most commonly found among the five patients with persisting biological activity.
Currently, available laboratory tests to confirm the clinical suspicion of persisting BU activity or relapse after BU specific treatment are unsatisfactory.
For persisting disease activity, RTX induction regimen consisting of two infusions of 1 g each, given 2 weeks apart, was administered.
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