This may be the result of these volcanoes being persistently active and showing similar patterns of activity over medium timescales, and more information about them being available.
While for PsA this has not yet been established, the task force regarded the need to measure disease activity and amend therapy with persistently active disease as a general necessity and, therefore, as a principle.
In detail, after a median of three CYC boluses administered monthly (median dose of 1,000 mg per bolus), four patients had persistent severe cardiac involvement, five patients had persistently active or deteriorating peripheral neuropathy, three patients had increasing pulmonary infiltrates, and one patient had skin vasculitis.
Age, female sex, having ever smoked, long-standing illness, arthritis, obesity, and depressive symptoms were associated with a lower likelihood of being persistently active (defined as reporting moderate and/or vigorous physical activity at least once a week over all 6 assessment points).
Synaptic activity-triggered Ca 2+ influx through NMDA receptor channels can activate CaMKII and promote its autophosphorylation at Thr286, which results in a persistently active form of the kinase.
We found persistently active neurons in both areas.
This work reveals, in humans, direct evidence for a distributed network of persistently active neurons supporting working memory maintenance.
In November 2000 the first system was deployed at Pu'u 'O'o (Kilauea, Hawai'i) to target persistently active vents.
PURPOSE: To compare the efficacy of two regimens of intravitreous fomivirsen for treatment of cytomegalovirus (CMV) retinitis that had reactivated or was persistently active despite other anti-CMV therapies in patients with acquired immunodeficiency syndrome (AIDS).
A combined therapeutic approach with any two immunosuppressants, including azathioprine, cyclosporine-A, cyclophosphamide, mycophenolate mofetil, and methotrexate was adopted in 18 patients (17.3%) with severe complications at diagnosis or with persistently active or recurrent disease.
Persistently active volcanoes, typically erupting frequently over a period of 10 years or more, tended to have more information available, be considered less hazardous and perceived as easier to understand.
