Sentence examples for persistently activated from inspiring English sources

Among the multitude of potential causes for retinal degeneration by a persistently activated UPR, the activation of inflammatory signaling is especially intriguing.

Signal transducer and activator of transcription 3 (STAT3) is persistently activated in squamous cell carcinoma of the head and neck (SCCHN) and can cause uncontrolled cellular proliferation and division.

- STAT3 is persistently activated in cancer cells due to aberrant activation of JAK, Src and/or other tyrosine kinases.

Recent work conducted with ADRP mice has revealed that the persistently activated UPR could be responsible for promoting retinal degeneration via the activation of an inflammatory response.

It is persistently activated in many human cancers.

STAT3, persistently activated in melanoma, has been shown to regulate the transcription of a panel of genes involved in several oncogenic features, such as cell proliferation, apoptosis and metastasis28.

A persistently activated signaling network is triggered by the DNA strand breaks.

The transcriptional network becomes less malleable in persistently activated T cells.

Introduction of a persistently activated STAT5A mutant (S711F) enabled erythropoiesis in an EPO-independent manner [16].

In this situation, however, c-Myc appears to be persistently activated judging by the high number of its direct targets present in both sets.

Furthermore, if the spindle checkpoint was persistently activated by depletion of Hec1 (Fig. 5C ), simultaneous depletion of hSgo1 resulted in complete loss of sister cohesion (Fig. 5D ).