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CD8+ cytotoxic T lymphocyte (CTL) responses are crucial in establishing the control of persistent virus infections.
Greg later told me that he had a persistent virus that kept him at home, "under observation," when his father was writing the novel.
North Korea did not elaborate on what it called "intensive and persistent virus attacks" on its Internet servers.
IFN-I blockade both prior to and following establishment of persistent virus infection was associated with virus clearance and was CD4 T cell dependent.
Brooks, D. G., Lee, A. M., Elsaesser, H., McGavern, D. B. & Oldstone, M. B. IL-10 blockade facilitates DNA vaccine-induced T cell responses and enhances clearance of persistent virus infection.
Homann, D. et al. Evidence for an underlying CD4 helper and CD8 T cell defect in B cell-deficient mice: failure to clear persistent virus infection after adoptive immunotherapy with virus-specific memory cells from muMT/muMT mice.
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Persistent viruses tend to grow weaker over the years.
Persistent Viruses (eds Stevens, J. & Todaro, G.) (in the press).
Pulko, V. et al. Human memory T cells with a naive phenotype accumulate with aging and respond to persistent viruses.
Hasenkrug focuses on HIV and other persistent viruses at the Rocky Mountain Laboratories, part of the NIH's National Institute of Allergy and Infectious Diseases.
Understanding the factors that impede immune responses to persistent viruses is essential in designing therapies for HIV infection.
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