Sentence examples for persistent vaccine from inspiring English sources

Others confirm these results by demonstrating that loss of vaccine antigen expression in muscle cells became apparent approximately cotemporaneously with the initial detection of antigen-specific T cells to the same immunogen and that persistent vaccine antigen expression was associated with poor vaccine immunogenicity [36].

Exposure to an environmental species which naturally sensitises individuals to Ag85 makes a persistent vaccine effect more difficult to ascertain with increasing age.

These data strongly support the role of the AS04 adjuvant, which includes the immunostimulant MPL, in triggering a persistent vaccine-induced immune response of high quality.

Immunodeficient persons with persistent vaccine-related poliovirus infection may serve as a potential reservoir for reintroduction of polioviruses after wild poliovirus eradication, posing a risk of their further circulation in inadequately immunized populations.

Immunodeficient persons with persistent vaccine-related poliovirus infection may serve as a potential reservoir for reintroduction of polioviruses into the general population after wild poliovirus eradication, posing a risk of their further circulation in inadequately immunized populations.

Our data provides a list of candidate genes that could be targeted for novel therapeutics or gene deletion to create a non-persistent vaccine strain (Tables  3 and 4).

We have studied immune activation levels and cytokine responses to a panel of persistent herpesviruses (CMV, EBV, HSV and VZV) and a non-persistent vaccine antigen (TT) in a cohort of patients with untreated chronic HIV-1 infection and compared them to responses in HIV-negative controls.

This reemergence was the consequence of persistent suboptimal vaccine coverage in toddlers and insufficient catch-up vaccination in older cohorts, leading to the growth of a large reservoir of susceptible persons.

However, challenge with SIVsmE543-3 induced persistent low vaccine VL in Mm0515, while the challenge virus remained undetectable.

Interestingly, ΔsecA2ΔlysA vaccinated mice also showed significantly lower lung bacillary loads than mice vaccinated with ΔsecA2 (0.35-log reduction in lungs of ΔsecA2ΔlysA versus ΔsecA2 vaccinated mice; P<0.05) (Figure 5A), an effect that may relate to the enhanced stability of memory cells in response to non-persistent live vaccines [14], [15], [16].

Current challenges to the final eradication of paralytic poliomyelitis include the continued transmission of wild polioviruses in endemic reservoirs, reinfection of polio-free areas, outbreaks due to circulating vaccine-derived polioviruses, and persistent excretion of vaccine-derived poliovirus by a few vaccinees with B-cell immunodeficiencies.